SMAD4 and cancer: Among the HR-NB associated genes (including the two prognostic GSPs, the MA_hi and MN_hi genes, and the genes with somatic mutations), we discovered eight commonly enriched transcription regulators and a cancer module previously described in multiple cancer types (KRAS,EED, HFH3, SMAD4 and PRC2 components for MN_hi whereas MYCN, MYC and E2F4 for MA_hi genes, FDR < 0.01, odd ratio = 2).