This may suggest a role for SIRT2 in the axonal degeneration cascade of neurodegenerative disorders of aging such as MS (McSharry, 2010), ALS (Fischer‐Hayes et al., 2013), X‐linked adrenomyeloneuropathy (X‐AMN) (Fourcade et al., 2015), or the hereditary spastic paraplegias (Fink, 2013). The gene discussed is SIRT2; the disease is adrenomyeloneuropathy.