This may suggest a role for SIRT2 in the axonal degeneration cascade of neurodegenerative disorders of aging such as MS (McSharry, 2010), ALS (Fischer‐Hayes et al., 2013), X‐linked adrenomyeloneuropathy (X‐AMN) (Fourcade et al., 2015), or the hereditary spastic paraplegias (Fink, 2013). Here, SIRT2 is linked to amyotrophic lateral sclerosis.