For example, upon inhibition or deletion of SIRT2, stimulation of the immune response by lipopolysaccharide (LPS) led to an overt production of pro‐inflammatory cytokines in an experimental model of colitis and after traumatic brain injury (Lo Sasso et al., 2015; Yuan et al., 2016), suggesting a role for SIRT2 in inhibiting the inflammatory response. The gene discussed is SIRT2; the disease is colitis.