Identifying patients with insulin-treated type 2 diabetes at high risk of hypoglycaemia would be clinically helpful in guiding management (e.g. in setting appropriate glycaemic targets and levels of glucose monitoring) and would potentially allow consideration of treatment strategies for high glucose variability traditionally used in type 1 diabetes, such as carbohydrate counting and use of subcutaneous insulin pumps. Here, INS is linked to type 1 diabetes mellitus.