In the last few years, the importance of MYC deregulation has become more apparent; it has been shown to be present in virtually all cases of BL (12, 20), and although present in a minority of DLBCL (3–16%) (12, 14), its presence in DLBCL is associated with poor response to treatment and a poor overall prognosis (21–23). Here, MYC is linked to diffuse large B-cell lymphoma.