IKBKG and colitis: Autoimmune haemolytic anaemia and immune thrombocytopenia have both been reported in IKBKG deficiency, and colitis is a common inflammatory complication.12, 13, 14 Hepatic granuloma have been only been reported in hypofunctional IKBKG due to disseminated mycobacterial infection.13 A liver biopsy performed on P1 found no evidence of mycobacteria or other pathogens, suggesting that the granuloma are sterile and due to immune dysregulation.