Statistically significant differences were present among GOLPH3 expression in the three previous groups collectively (P = 0.001) and between BPH vs. PC (P = 0.0031), PIN vs. carcinoma (P = 0.002), while there was no statistically significant difference between BPH vs. PIN (P = 0.098). The gene discussed is GOLPH3; the disease is pachyonychia congenita.