In PC cases, a significant positive correlation was noted between GOLPH3/nuclear and cytoplasmic YB-1 expression (r = 0.777, P < 0.001 and r = 0.438, P < 0.001 respectively) and between nuclear/cytoplasmic YB-1 expression (r = 0.611, P < 0.001). This evidence concerns the gene GOLPH3 and pachyonychia congenita.