ANO1 and melanoma: Moreover, DOG1 showed high specificity for GISTs, as only one case of poorly differentiated carcinoma was focally immunoreactive for DOG1 (Fig. 1g), compared to five cases of non-GISTs (one case of leiomyosarcoma (Fig. 1h), two cases of melanoma and two poorly differentiated carcinoma) that showed focal C-KIT-positive expression.