INS and type 2 diabetes mellitus: As anticipated, peripheral insulin sensitivity, i.e., the glucose infusion rate, normalized to body weight, required to maintain euglycemia during the hyperinsulinemic-euglycemic clamp, was significantly lower in T2DM patients compared to non-diabetic obese/overweight individuals (14.5 ± 2.0 vs. 26.6 ± 2.5 μmol/min/kg, respectively; p = 0.0011).