TP53 and malignant colon neoplasm: TQ was observed to induce apoptosis in the human colon cancer cells and animal models through p53 dependent pathway (Gali-Muhtasib et al., 2004, 2008) which caused 2.5- to 4.5-fold surge in mRNA appearance of p53 and the decrease in p53 target gene, p21WAF1 (Gartel et al., 1996; Gartel and Tyner, 1998).