In other reports, we reported the phenotypes of the α9, α10, α9α10, and α7α9 knockouts in an Experimental Autoimmune Encephalitis (EAE) model of Multiple Sclerosis using our KO models (Simard et al., 2013; Liu et al., 2017). The gene discussed is IGKV1D-22; the disease is autoimmune encephalitis.