Compared with the general population, patients with the milder form of Gaucher’s disease (type 1) have a 20-fold increased lifetime risk of developing parkinsonism7, whereas the odds ratio for any GBA mutation in PD patients compared to controls was greater than 5 in a multi-center analysis including more than 5000 cases and 4000 controls8. The gene discussed is GBA1; the disease is Parkinson disease.