In this frame, we investigated GBA/GBAP1/miR-22-3p expression pattern in disease-relevant tissues using in-silico analyses of microarray datasets publicly available through the Gene Expression Omnibus repository (see Supplementary Materials and Methods), as well as in-vivo measurements performed on RNA extracted from iPSCs and iPSC-derived neuronal cells of PD cases and controls. Here, GBA1 is linked to Parkinson disease.