However, the absolute treatment effects were also obtained using the trial data, and people with myocardial infarction enrolled in clinical trials are on average younger, less frequently hospitalised, at lower risk of adverse events and less likely to have comorbid disease than people with myocardial infarction identified in disease registers.10 11 Moreover, the previous review included patients treated with intravenous P2Y12 inhibitors during elective percutaneous coronary intervention as well as patients with stable coronary disease. Here, P2RY12 is linked to myocardial infarction.