CURE, COMMIT and CLARITY-TIMI 28 compared clopidogrel with placebo in ACS, CHANCE and SPS3 compared clopidogrel with placebo in stroke, SOCRATES compared ticagrelor with aspirin in stroke and TRITON-TIMI 38, PLATO and TRILOGY ACS compared the novel P2Y12 antagonists with clopidogrel in ACS. The gene discussed is P2RY12; the disease is stroke disorder.