In a meta-analysis and modelling study using data from 100 000 participants randomised to P2Y12 inhibitors and over 45 000 patients from the Scottish population hospitalised with myocardial infarction, we have identified that newer P2Y12 inhibitors may be slightly less efficacious in women than men but that the ARR is similar in both sexes. This evidence concerns the gene P2RY12 and myocardial infarction.