FUT8 and breast cancer: To investigate whether FUT8 is functionally involved in regulating the aggressiveness of breast cancer cells, we examined the expression of FUT8 in epithelial-like normal human epithelial cells (MCF-10A), low-metastatic breast cancer cells (T-47D) and mesenchymal-like highly invasive breast cancer cell lines (MDA-MB-231 and Hs578T) (Fig. 3a).