To further investigate the potential utility of this approach for modelling other types of uterine malignancies we generated a series of five different MuLE lentiviruses designed to reproduce the genetics of uterine leiomyomas and uterine leiomyosarcomas, namely i) overexpression of HMGA2, ii) expression of MED12G44S, iii) expression of MED12G44S plus shRNA against Trp53, iv) expression of shRNA against Fh or v) expression of shRNA against Fh plus shRNA against Cdkn2a. Each vector also expressed luciferase. The gene discussed is HMGA2; the disease is leiomyosarcoma.