KRAS and pancreatic ductal adenocarcinoma: We next sought to explore the activity of dual node targeting in Kras mutant genetically engineered mouse (GEM) models, including a pancreatic ductal adenocarcinoma (PDAC) model (LSL-KrasG12D/+; p16/p19fl/fl; Pdx1-CRE) and a NSCLC model (LSL-KrasG12D/+;p53frt/frt).