In contrast to CD150, cytoplasmic CD180 in csCD180- CLL cases was colocalized with a marker of early endosomes—EEA1 (Fig 3C), but had only a low degree of colocalization with markers of the ER—GRP78 (R = 0.24±0.05; R[r] = 0.20±0.05), Golgi apparatus—TGN38 (R = 0.23±0.04; R[r] = 0.22±0.03), and lysosomes—LAMP1 (R = 0.23±0.05; R[r] = 0.19±0.03). Here, TGOLN2 is linked to B-cell chronic lymphocytic leukemia.