CD150- B-cell malignancies include pre-B acute lymphoblastic leukemia, small lymphocytic lymphoma, sporadic Burkitt’s lymphoma, germinal center subtype of diffuse large B-cell lymphoma, lymphoplasmacytic lymphoma, and primary cutaneous marginal zone B-cell lymphoma [27,31–33]. The gene discussed is SLAMF1; the disease is B-cell chronic lymphocytic leukemia.