Since phosphorylation/dephosphorylation are key post-translational modifications that dynamically coordinate cell signaling networks, we checked the basal level of tyrosine phosphorylation and phosphorylation of serine/threonine specific motifs that are substrates for either the AMPK, Akt, PKA, PKC, or CDK kinases in CLL B cells taking into consideration cell surface CD150 expression. This evidence concerns the gene PRRT2 and B-cell chronic lymphocytic leukemia.