Akt-mediated inactivation of GSK3β and FOXO after CD150 and CD180 stimulation suggests a pro-survival role for these receptors in CLL B cells pathobiology, while cross-talk between CD180 and BCR can redirect signaling from pro-survival to pro-apoptotic pathways [37]. This evidence concerns the gene SLAMF1 and B-cell chronic lymphocytic leukemia.