TNFSF14 and colitis: TNFSF14 has been suggested to be an important mediator of the pathogenesis in CD and in murine models neutralizing antibodies for TNFSF14 has reduced symptoms of induced colitis.[34] Conflicting results for TGF-alpha have been published before with increasing numbers of TGF-alpha containing cells in inflamed mucosa in UC, in contrast to the results of another study showing relatively lower protein signals in inflamed biopsies compared to non-inflamed biopsies in both CD and UC.[35, 36]