An alternative interpretation is that effect of MR16-1, a rat IgG, was masked due to the immune response against rat IgG in mice as suggested previously [25], although we used a protocol to induce a tolerance in mice against rat IgG [16] and a number studies have shown the suppressive effect of MR16-1 on IL-6 signaling, including those for cardiovascular disease [26–28]. Here, IL6 is linked to cardiovascular disorder.