As HDAC2 is aberrantly expressed in several types of cancer including gastric, colorectal, prostate and Hodgkin’s Lymphoma [18–20], distinguishing the precise functions of HDAC2 remains important for understanding epigenetic mechanisms of human diseases, as the contribution of HDAC2 to tumorigenesis may involve functions that are independent of HDAC1. This evidence concerns the gene HDAC2 and Hodgkins lymphoma.