SHBG and obesity due to melanocortin 4 receptor deficiency: Obesity studies should include measurement of reproductive hormones, as the only meta-analysis paper (MacDonald et al., 2010) that included hormonal parameters concluded ‘There was strong negative relationship for testosterone, SHBG and free testosterone with increased BMI.’ In a recent cross-sectional study, (Andersen et al., 2015) the correlation between the three hormones and obesity was affirmed.