RUNX2 and posterior cortical atrophy: Moreover, we noted strong evidence for differential expression for MYC, a well-known oncogene [43] located in frequently amplified region 8q24 in PCa, and FOXO1, a key downstream effector of the tumour suppressor PTEN and critical gene in negative regulation of transcription factor RUNX2, which are also significantly deregulated according to results derived from O-miner.