The potential mechanisms involved in the association between rs12503843 and the riskof HCC may include the ability of this SNP to exert a functional role and to act asa marker in tight LD with other functional SNPs in the HPSE 3’UTR.Ostrovsky et al. (2007)have shown that SNP rs4693602, which maps to a distal part of the 3’-UTR of theHPSE gene, was associated with multiple myeloma (MM) and maymodify HSPE expression. The gene discussed is HPSE; the disease is AL amyloidosis.