Interestingly, in line with our observation of higher Survivin levels in sera and plasma from AA-PCa patients compared to EA-PCa patients (Fig 1), there was also a significantly elevated (3–4 fold) AChE activity, indicative of increased EV release, in AA-PCa derived plasma samples compared to EA-PCa derived plasma (P<0.01) (Fig 2A). Here, ACHE is linked to posterior cortical atrophy.