SVR24 was not achieved in those not achieving EVR [OR (95% CI) = 198 (15.7–2900), p<0.0001], having portal hypertension [OR (95% CI) = 19 (3.3–110.4), p<0.0001], splenectomy [OR (95% CI) = 9.8(1–103.7), p = 0.05], elevated AFP [OR (95% = 9.1(1.6–51.3) p = 0.01], high serum bilirubin [OR (95% CI) = 9.7(1.71–55.2) p = 0.01], low hemoglobin level [OR (95% CI) = 21(1.3–335.3) p = 0.03], prediabetic state [OR (95% CI) = 6.5 (1.1–39.1), p = 0.04], TFT-T3 [OR (95% CI) = 0.3 (0.2–1), p = 0.04], or TFT-T4 [OR (95% CI) = 1.2 (1–1.4), p = 0.046], and low platelet count [OR (95% CI) = 1 (1–1) p = 0.043]. This evidence concerns the gene AFP and portal hypertension.