The Drosophila melanogaster model was used to study the mutations in lamins identified in muscular dystrophy patients, showing that aggregation of cytoplasmic lamins are associated with elevated levels of GSH and NADPH, and with elevated p62/SQSTM1, and nuclear enrichment of NrF2, leading to RS [84]. The gene discussed is SQSTM1; the disease is muscular dystrophy.