Overall, since the NDRG1 promoter was shown to be hypermethylated in the NAWM of MS patients [17], our results indicate that TGFB1 and/or PDGFC released in MS periplaques could be responsible for a silencing of NDRG1 in periplaques and, to a lesser extent, in the NAWM. This evidence concerns the gene PDGFC and myeloid sarcoma.