In particular, previous studies demonstrated that NAWM in MS brains or spinal cords exhibit: (i) signs of low-grade inflammation [9,10] and astrocytosis [11,12,13]; (ii) an abnormal lipid and protein composition of myelin sheaths [14,15,16]; and (iii) an epigenetic silencing of the oligodendrocyte gene NDRG1 (N-myc downstream regulated 1) [17]. This evidence concerns the gene NDRG1 and myeloid sarcoma.