For example, Sesn2-deficient mice have shown an impaired activation of cardiac AMPK and their hearts presented larger myocardial infarcts compared to their wild-type littermates.6 Furthermore, AMPK reactivation in Sesn2-KO mice restored hepatic insulin sensitivity.5 AMPK is likewise activated in the cochlear spiral ligament following acoustic overstimulation.10 Finally, depletion of Sens2 by RNA interference resulted in reduction of autophagy.11 Whether the stress caused by gentamicin in auditory hair cells also implicate Sesn2 is unknown. The gene discussed is SESN2; the disease is myocardial infarction.