E2F1 and acute myeloid leukemia: Previous studies reported that miR-223 and three TFs (C/EBPα, NFI-A and E2F1) play critical roles in granulocyte differentiation and the occurrence of acute myelocytic leukemia.32 Ma et al.33 found a positive feedback loop comprised of KLF3 and miR-23a promoting the expression of β-like globin genes and the miR-23a/27a/24-2 cluster during erythropoiesis.