Previously, it has been reported that the inactive DUB of Marek’s disease herpesvirus compromises the ability of that virus to cause lymphoma in chickens.15 In addition, reports suggest that deregulation of cellular DUBs could also promote various cancer types in humans and mouse.16, 17, 18 However, HCMV-DUB and its role in oncogenesis are not known. This evidence concerns the gene ZUP1 and cancer.