In addition, mutp53-R273H or mutp53-R175H (another important hotspot mutation that usually occurred in cancer43) overexpression decreased BA-induced proliferation inhibition and apoptosis in HCT116 p53−/− cells (Figures 7c and d; Supplementary Figure S7A; Figure 8a, right), whereas p53 silencing augmented BA-induced proliferation inhibition and apoptosis in SW480 and HT29 cells with mutation p53 (Figures 7e and f; Supplementary Figure S7B; Figures 8b and c, left), indicating that mutp53 expression enhanced CRC cells' resistance to BA. The gene discussed is TP53; the disease is colorectal carcinoma.