As we all know, wtp53 as a tumor suppressor protein has been implicated in apoptosis.69 It was reported that BA triggered apoptosis without activation of p53 in neuroectodermal and breast cancers.53, 75 Thus, it undoubtedly prompted us to question why and how BA treatment affects p53 expression in CRC cells. This evidence concerns the gene TCHP and colorectal carcinoma.