By concomitant induction of autophagy and inhibition of the autophagic flux, B10 turns autophagy into a cell death mechanism.36 Moreover, another research showed that BA decreased phosphorylation of AKT and degraded EGFR in company with induction of autophagy in bladder cancer, which also resulted in autophagic cell death.68 In our study, we found BA-induced autophagy by reducing phosphorylation of AKT and MTOR in CRC cells, and autophagy inhibition caused more cell death, indicating that BA-induced autophagy by AKT-MTOR signaling has a cytoprotective effect in CRC cells. This evidence concerns the gene AKT1 and colorectal carcinoma.