miR-218 has been observed to induce CRC cell apoptosis by inducing p53 expression64 and AKT-mTOR inhibition, which is a major pathway to regulate autophagy.73 However, miR-502, which could inhibit autophagy in CRC cells, had potential p53-binding sites in their putative promoter regions and was regulated by p53 via a negative feedback regulatory mechanism.65, 74 Therefore, it is possible that BA upregulates miR-218 to induce p53 within a short-time treatment and p53 degradation may increase miR-502, which will inhibit protective autophagy overaccumulation. This evidence concerns the gene AKT1 and colorectal carcinoma.