TP53 and colorectal carcinoma: Moreover, mutp53 transfection enhanced BA-induced autophagy and inhibited the sensitivity of HCT116 p53−/− to BA (Figures 7c and d), whereas mutp53 silencing in mutp53-harbored SW480 and HT29 cells inhibited BA-induced protective autophagy and augmented BA-induced apoptosis (Figure 7f and Supplementary Figure S7B), suggesting that this mutp53-promoted and BA-induced autophagy have a role in mutp53-induced BA resistance in CRC cells.