TP53 and colorectal carcinoma: In addition, it is known that several miRNAs (e.g., miR34a, miR-218 and miR-502) were involved in p53-mediated cell cycle regulation, autophagy and apoptosis in CRC cells.64, 65, 66 Interestingly, we found that BA treatment can induce miR-218 expression in three CRC cells, as well as significantly enhance miR-502 expression in HCT116 and HT29 cells and slightly accumulate miR-502 in SW480 cells (Supplementary Figure S15).