AKT1 and breast cancer: We observed the induction of RAS/JNK signaling by dexamethasone, whose relation to dexamethasone-induced anti-apoptotic signaling in breast cancer by interaction with protein kinases PI3-K and Akt is well known.45 This matches to our data, because PI3-K and Akt are the best-characterized RAS effectors.26 Other involved key players may be the serum and glucocorticoid-regulated kinase-1 (SGK1), as reported by Conzen and colleagues10, 46, 47, 48 in breast, ovarian and prostate cancer.