The glutathione (GSH) and the thioredoxin (TRX) system are two important ROS scavenging pathways that are often upregulated in cancer cells.18, 19 As the reduced form of GSH is the most abundant non-protein thiol in the cell,20 changes in intracellular GSH levels have an important role in regulating redox homeostasis. This evidence concerns the gene TXN and cancer.