NLRP3 and Hypertension: Vascular remodeling in hypertension may initially be adaptive, but eventually it becomes maladaptive and contributes to the development and complications of hypertension.32, 33 VSMC phenotypic transformation is as a major initiating factor for vascular remodeling in hypertension.3 VSMC proliferation are closely linked with vascular remodeling and hypertension.34 Therefore, the therapeutical effects of NLRP3 gene silencing on vascular remodeling and hypertension were examined in SHR.