NLRP3 inflammasome can be activated by a wide range of danger signals that derive not only from microorganisms but also from a variety of signals and metabolic dysregulation such as Ca2+ signaling, reactive oxygen species (ROS), nitric oxide (NO), Ang II, endoplasmic reticulum stress and mitochondrial dysfunction.25, 26 However, the mechanisms of NLRP3 inflammasome activation in hypertension are not well known. This evidence concerns the gene NLRP3 and hypertensive disorder.