SNHG20 and hepatocellular carcinoma: In addition to these findings, upregulation of SNHG20 was also found to predict poor prognosis in colorectal cancer and hepatocellular carcinoma.24, 25, 26 Moreover, loss or gain of function assays revealed that SNHG20 downregulation led to a marked inhibition of proliferation and migration in vitro, and suppression of tumor growth in vivo.