We have previously demonstrated that L-plastin is a potential biomarker for PCa progression.15, 21 To determine whether L-plastin functions in CRPC progression, we established an androgen-independent LNCaP subline known as LNCaP-AI using previously described methods.22, 23, 24 LNCaP cells have an epithelial morphology and feature tapered unbranched processes; LNCaP-AI cells exhibit a neuronal morphology with compactly rounded cell bodies (Figure 1a). Here, LCP1 is linked to posterior cortical atrophy.