Although the isoform of L-plastin expressed in haematopoietic cell lineages is not active in most normal cells, it is ectopically activated and upregulated in various types of solid malignant tumours in humans.12, 13 Overexpression of L-plastin is involved in PCa invasion and metastasis both in vitro and in vivo. The gene discussed is LCP1; the disease is posterior cortical atrophy.