TP53 and cancer: It has been shown to exert a cancer-specific proapoptotic function by affecting the response to fenretinide-induced apoptosis through a p53-independent.21, 32 It has also been reported that the increase in the level of RTN1-C protein leads to ER stress-induced cell death and significantly sensitizes cells to different ER stress inducers, whereas the reduction in RTN1-C protein levels dampens the response to ER stressors.