RTN1 and brain ischemia: Previous studies suggested that RTN1 might be involved in the pathogenesis of human diseases, principally neurodegenerative disorders.21, 23, 26 To determine whether RTN1 is involved in cerebral ischemia/reperfusion (I/R) injury, we performed western blot to detect the expressions of the three splice variants of RTN1 in the brain tissue samples of MCAO rats.