Another study demonstrates that miR-19a can negatively regulate NBR2 and AMPK, probably by base pairing between miR-19a and NBR2 or miR-19a and PRAA1 (the gene encoding AMPK).40 The upregulation of miR-19a in acute liver failure (ALF) results in the downregulation of NBR2 and AMPK expression, which represses autophagy. This evidence concerns the gene NBR2 and acute liver failure.