Studies have demonstrated that downregulation of the lncRNA HOTARIM1 can block autophagy, and thus inhibit all-trans retinoic acid (ATRA)-induced autophagic degradation of PML-RARA in promyelocytic leukemia (PML) cells.51, 52, 53HOTAIRM1 may provoke autophagy by preventing miR-20a/106b and miR-125b from decreasing ULK1, E2F1 and DRAM2 expression, thus contributing to autophagy-dependent degradation of PML-RARA.53, 54, 55, 56 This indicates that overexpression of HOTAIRM1 might be a potential therapeutic measure for PML. Here, RARA is linked to acute promyelocytic leukemia.