Two studies have demonstrated that the inhibition of LincRNA, regulator of reprogramming (Linc-ROR) can elicit autophagy by upregulating Beclin 1 expression, and revise gemcitabine and tamoxifen resistance in breast cancer respectively.80, 81 However, further experiments need to reveal how Linc-ROR regulates Beclin 1 expression and whether knockdown of Linc-ROR could be feasible in clinical practice. The gene discussed is BECN1; the disease is breast cancer.