The lncRNA HNF1A-AS1 can sequester miR-30b from binding to its target ATG5 and thereby provoke autophagy in HCC.95 In addition, Beclin 1 and ATG12 have also been defined as targets of miR-30b in a previous study, indicating that, aside from ATG5, HNF1A-AS1 might also upregulate Beclin 1 and ATG12 expression to promote vesicle nucleation and autophagosome elongation/closure.95, 96 Considering that autophagy was previously confirmed to promote HCC, it is likely that HNF1A-AS1 facilitates HCC biogenesis by promoting autophagy.97, 98, 99. Here, ATG5 is linked to hepatocellular carcinoma.