As lncRNA expression is prevalent along the developmental and spatial axis, and several autophagy-associated lncRNAs described in this review virtually exhibit tissue specificity, such as HULC and PCA3, lncRNAs may serve as biomarkers of specific diseases, and pertinent therapeutic measures may be developed.103, 133 Finally, both lncRNAs and autophagy are involved in a vast range of diseases including cancer; therefore, a joint intervention targeting lncRNAs and autophagy may be a promising therapeutic method. This evidence concerns the gene HULC and cancer.