PLEKHM1 and cardiac hypertrophy: The lncRNA cardiac hypertrophy-associated transcript (Chast) can suppress autophagy via downregulating Plekhm1 and possibly ATG5 expression to induce cardiomyocyte hypertrophy (Figure 5).120 This study sheds light on the mechanism of Chast/Plekhm1 interaction during autolysosome fusion and implies that Chast is a possible target for the prevention of cardiac remodeling.