KMT2A and acute myeloid leukemia: Cleavage of a region of the mixed myeloid lineage (MLL) gene could be induced by drugs that target topoisomerases or (to a lesser extent) by apoptotic stimuli including death ligands.24, 25, 26, 27 The DNA-strand breaks within MLL appeared to involve error-prone repair via non-homologous end joining (NHEJ), which may contribute to the high incidence of chromosomal translocations associated with therapy-related acute myeloid leukemia.28 CAD has been directly linked to DNA damage in various contexts.