SNCA and Parkinson disease: The deposition of protein aggregates could be caused by disruption of degradation pathways, which accordingly shares linkages to cellular toxicity.3 Particularly, mounting evidence suggests that autophagy-lysosomal pathway is a rate-limiting, major pathway involved in the clearance of damaged and aggregated proteins under stress conditions.4 Among the research field of Parkinson’s disease (PD), recent progressions have shown that α-synuclein, LRRK2, Parkin, PINK1, ATP13A2, Rab7L, and VPS35 are linked to autophagy pathways.1, 5, 6, 7