Trehalose has been shown to be protective against neurotoxicity and facilitates the clearance of protein aggregates in HD and PD cell and mouse models.19, 22, 23, 24, 40 To determine the effects of trehalose and other sugars on α-synuclein aggregation and secretion, differentiated SH-SY5Y cells were transduced with recombinant α-synuclein adenoviral vectors (adeno/α-syn). This evidence concerns the gene SNCA and Huntington disease.