Exploitation of ER stress and the UPR have been considered as a means to eliminate cancer cells.32 CHOP-mediated DR5 induction is considered an important event in cell death activation downstream of the UPR.9, 15, 24 Here, we demonstrate that DR4 is generally more important in the initiation of cell death downstream of Golgi stress and, in some cases, ER stress (Figure 2). The gene discussed is TNFRSF10B; the disease is cancer.