FGF19 and steatosis: Interestingly, basal circulating FGF19 levels are lower in older individuals compared with young healthy people.72 Given the important regulatory role of FGF19 in liver fat metabolism,22, 33 its reduced availability in older persons may underlie the steatosis commonly found in this population.47, 48 Steatosis represents a significant obstacle to a successful liver regeneration.19, 20 Its attenuation by Fibapo may explain in part the decreased injury and improved liver regeneration found in aged mice.