KRAS and familial pancreatic carcinoma: Kras mutations are common in human pancreatic cancer (Bailey et al., 2016; Hezel et al., 2006; Jones et al., 2008), and are present with high frequency in the precursor lesions to pancreatic cancer known as Pancreatic Intraepithelial Neoplasia (PanIN) (Kanda et al., 2012; Klimstra and Longnecker, 1994).