Serum testosterone levels differ by ethnic group.24 The EMAS study20 found that low testosterone levels were related to obesity and the metabolic syndrome (that increase with age), not just age alone, although sex hormone binding globulin (SHBG) levels increase with age with consequent decrease in free testosterone levels.25 A total testosterone level <8 nmol/L has been proposed as a putative risk stratifier in the risk assesment for T2DM, CVD and all‐cause mortality.26 Patients with late onset HG should be considered for TRT and their symptoms monitored to assess benefit. The gene discussed is SHBG; the disease is obesity due to melanocortin 4 receptor deficiency.