Importantly, six proteins (Haptoglobin, Apolipoprotein A‐IV, Complement C4, Beta‐2‐microglobulin, Alpha‐1‐acid glycoprotein, and Dipeptidyl peptidase 1) were significantly changed during the entire tumor progression with a fold change >1.5 and P < 0.05, suggesting the potential for these urine proteins to be used for the early detection of cancer. This evidence concerns the gene CTSC and cancer.