Carriers of the endothelial lipase gene (LIPG) 396Ser allele (2.6% frequency, and have high plasma HDL-C levels) were expected to decrease the risk of myocardial infarction (MI) by 13% (odds ratio [OR] = 0.87, 95% confidence interval (CI) = 0.84–0.91), however no decrease in the risk of MI was detected in 396Ser allele carriers (OR = 0.99, 95% CI 0.88–1.11, p = 0.85)8. This evidence concerns the gene LIPG and myocardial infarction.