Importantly, iPSC-derived MPC significantly decreased the frequency of central nuclei and mitigated the tissue fibrosis in DMD muscle which was accompanied by enhanced Pax7 expression, redistribution of dystrophin, and reconstitution of acetylcholine receptors thus suggesting a strong therapeutic potential of iPSCs derived muscle progenitors in the treatment of muscular dystrophy. The gene discussed is PAX7; the disease is muscular dystrophy.