We aim to study volumetric differences along the anterior-posterior axis of this region in relation to Aβ42 and P-tau levels in cerebrospinal fluid (CSF; as a proxy for tau and Aβ pathology) and memory performance in cognitively normal participants (CN), subjects with subjective cognitive decline (SCD) and subjects with amnestic MCI. The gene discussed is MAPT; the disease is Mental deterioration.