In this context, and because of its major modulatory impact in synaptic plasticity (Tzingounis and Nicoll, 2006; Bloomer et al., 2008; Park et al., 2008; Waung et al., 2008; Bramham et al., 2010; Gao et al., 2010; Ren et al., 2014; Wang et al., 2016), a role of Arc genetics in a number of different neurological and psychiatric disorders is not surprising (Greer et al., 2010; Cao et al., 2013; Ebert and Greenberg, 2013; Li et al., 2015). Here, ARC is linked to psychiatric disorder.