PRKAA2 and hepatocellular carcinoma: In line with this hypothesis, the authors indeed showed that metformin treatment suppresses BMP6-mediated hepcidin response both in hepatoma cells and primary hepatocytes, a suppressive effect that was attenuated by either SHP knockdown, treatment with a non specific inhibitor of AMPK (Compound C, also known as dorsomorphin) or a dominant negative form of AMPK.