Finally, FILNC1 knockdown in 786-O cells did not affect the levels of L-Myc or N-Myc, two other members of Myc family, under glucose starvation condition; indeed, L-Myc or N-Myc exhibited very low expression in the renal cancer cells used in this study (Supplementary Fig. 11A). The gene discussed is MYCN; the disease is renal carcinoma.