Collectively, our data strongly suggested that FILNC1 deficiency protects renal cancer cells from energy stress-induced cell death, resulting in increased anchorage-independent growth and tumor development in vivo, which is consistent with our data showing the induction of FILNC1 by FoxO transcription factor, a tumor suppressor in renal cancer19 (Fig. 1). This evidence concerns the gene FILNC1 and renal carcinoma.