SLC49A4 and renal carcinoma: Using FoxO(TA)ERT2 stable cell lines, we previously showed that reactivation of FoxO1 or FoxO3 transcription factor by 4OHT treatment (F1 + 4OHT or F3 + 4OHT), compared to vehicle treatment (F1 − 4OHT or F3 − 4OHT), in RCC4 or UMRC2 renal cancer cells induced many transcriptional alterations of protein-coding genes, resulting in cell cycle arrest and apoptosis19.