We should mention that, since these transcripts largely overlap, our following experiments on real-time PCR and shRNA-mediated knockdown, or analysis of RNA sequencing (RNA-seq) data from The Cancer Genome Atlas (TCGA) RCC data sets cannot definitively distinguish these three isoforms of FILNC1 gene, thus the data presented below may represent the concerted functions of these FILNC1 isoforms. The gene discussed is FILNC1; the disease is renal cell carcinoma.